Plexin A4 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885235

Der Kaninchen Polyklonal anti-Plexin A4 Antikörper (ABIN7885235) detektiert spezifisch Plexin A4 in WB, IHC, FACS und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Plexin A4 Antikörper (Extracellular, N-Term) (ABIN7885235)

Target: Plexin A4 (PLXNA4)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Plexin A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Plexin A4 Antikörper

Bindungsspezifität: AA 201-215, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal antibody to Plexin-A4 (extracellular)

Homologie: Human,Rat - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RKLTKNSEADGMFAY, corresponding to amino acid residues 201 - 215 of mouse Plexin-A4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Plexin A4

Target: Plexin A4 (PLXNA4)

Andere Bezeichnung: PLXNA4

Hintergrund:

Synonyms: PLXNA4

Description: The plexin family are transmembrane proteins which are classified into four subfamilies: plexin -A, B, C and D. The plexins serve as a receptor for seamaphorins (Sema), axon guidance molecules involved in cellular processes such as axon pruning and repulsion, regulation of cell migration, vascular remodeling and more1. All family members consist of a Sema domain at the N-terminus responsible for Sema binding. In addition, plexins have PSI and IPT (Integrin, Plexin, and Transcription factor) domains, which connect to the transmembrane (TM) helix. Moreover, intracellular region of all plexins contains a membrane proximal juxtamembrane region (JM), a Rho GTPase-binding domain (RBD), and GTPase Activating Protein (GAP) domain2.Plexin-A4 acts as a receptor for the secreted semaphorins Sema3A and Sema6A in the central nervous system, and mediates axon repulsion and synaptic plasticity. Moreover, genome-wide significant association study (GWAS) on humans, has identified that several single nucleotide polymorphisms (SNPs) in PLXNA4 can increase the risk of Alzheimer's disease (AD) 3,4.In the immune system, Plexin-A4 has been implicated in macrophage Toll-like receptor (TLR)-mediated signaling in sepsis, negative regulation of T-cell mediated immune responses in cancer5.

Gen-ID: 243743

UniProt: Q80UG2

Pathways: Regulation of Cell Size