NMNAT2 Antikörper (Intracellular)

Produktnummer ABIN7885201

Der Kaninchen Polyklonal anti-NMNAT2 Antikörper wird verwendet zum Nachweis von NMNAT2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für NMNAT2 Antikörper (Intracellular) (ABIN7885201)

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMNAT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-NMNAT2 Antikörper

Bindungsspezifität: AA 131-146, Intracellular

Verwendungszweck: A Rabbit polyclonal antibody to NMNAT2.

Homologie: Rat - identical,Human12,16 identical.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)HENTQPIYQNSNVPTK, corresponding to amino acid residues 131 - 146 of mouse NMNAT2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NMNAT2

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Andere Bezeichnung: Nicotinamide mononucleotide adenylyltransferase 2

Hintergrund:

Synonyms: Nicotinamide mononucleotide adenylyltransferase 2, Nicotinamide Nucleotide Adenylyltransferase 2, Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2, NMN adenylyltransferase 2

Description: Nicotinamide mononucleotide adenylyltransferase 2, also referred to as NMNAT2, belongs to the NMNAT family of enzymes responsible for NAD+ biosynthesis. This family catalyzes the final step in NAD+ production, converting nicotinamide mononucleotide (NMN) and ATP to NAD+. NMNAT2 is predominantly localized in the cytoplasm and Golgi apparatus, distinguishing it from NMNAT1 (nuclear) and NMNAT3 (mitochondrial) counterparts. Structurally, NMNATs share conserved ATP-binding motifs crucial for their enzymatic functions1-3. In addition to its enzymatic role, NMNAT2 also functions as a chaperone, mitigating protein aggregation under proteotoxic stress. Its enzymatic and chaperone activities are recruited in a context-dependent manner, protecting against excitotoxicity and proteotoxic stress, respectively. This dual functionality highlights its significance in cellular stress responses5. NMNAT2 plays a critical role in cellular energy metabolism by maintaining NAD+ pools, essential for redox reactions and the activity of sirtuins and PARPs, key regulators of gene expression and stress responses. NMNAT2's cytoplasmic localization facilitates its involvement in glucose metabolism and the regulation of compartmentalized NAD+ availability, which is crucial for processes like adipogenesis4. In neurons, NMNAT2 contributes to axonal protection and integrity by modulating NAD+-dependent repair pathways, highlighting its neuroprotective roles5. NMNAT2 protein levels are tightly regulated post-transcriptionally, with a short half-life necessitating constant replenishment, and its expression is induced by glucose metabolism3. Tissue-specific expression studies reveal that NMNAT2 is highly abundant in the brain, heart, and skeletal muscle, reflecting its importance in energy-demanding tissues. At the cellular level, its expression is notable in neurons, cardiomyocytes, and other metabolically active cells3-5. Clinically, reduced NMNAT2 levels have been observed in neurodegenerative diseases like Alzheimer's, where its decline precedes neurodegeneration, underscoring its potential as a therapeutic target. Dysregulated NMNAT2 activity has also been implicated in cardiac hypertrophy, demonstrating its broad relevance in disease pathophysiology1,3,5.

Gen-ID: 226518