NTSR2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7885195

Der Kaninchen Polyklonal anti-NTSR2 Antikörper wird verwendet zum Nachweis von NTSR2 in Proben von Maus und Ratte. Er wurde validiert für WB, IHC, IF und IC.

Kurzübersicht für NTSR2 Antikörper (C-Term, Intracellular) (ABIN7885195)

Target: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NTSR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Güteklasse: Carrier-free

Produktdetails anti-NTSR2 Antikörper

Bindungsspezifität: AA 377-392, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Neurotensin Receptor 2

Homologie: Mouse - 14,16 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:50-1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236129)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NTSR2

Target: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Andere Bezeichnung: NTR2

Hintergrund:

Synonyms: NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor

Description: Neurotensin receptor 2 (NTR2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR2 and NTR1 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+mobilization. However, the exact signaling mechanisms subsequent to NTR2 activation appear to depend on the species and on the cellular system in which the receptor is studied.NTR2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion.2The most established physiological role of NTR2 is its role in pain transmission as NTR2-defficient mice showed that NTR2 is the likely mediator of the neurotensin-induced analgesic responses.3

Gen-ID: 64636

UniProt: Q63384