NRP2 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885192

Der Kaninchen Polyklonal anti-NRP2 Antikörper wird verwendet zum Nachweis von NRP2 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, IHC, IF und FACS.

Kurzübersicht für NRP2 Antikörper (Extracellular, N-Term) (ABIN7885192)

Target: NRP2 (Neuropilin 2 (NRP2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NRP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Produktdetails anti-NRP2 Antikörper

Bindungsspezifität: AA 747-758, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuropilin-2

Homologie: Rat,mouse - 11,12 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)REDQGGEWKHGR, corresponding to amino acid residues 747-758 of human neuropilin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 1:15

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236118)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NRP2

Target: NRP2 (Neuropilin 2 (NRP2))

Andere Bezeichnung: Vascular endothelial cell growth factor 165 receptor 2

Hintergrund:

Synonyms: Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2

Description: The neuropilins (NRPs) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, and physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin co-receptors with plexins, as well as enhancers of cellular responses to members of the vascular endothelial growth factor (VEGF) family.The NRP family comprises two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2), which are usually expressed as homodimers but can also appear as heterodimers. NRP2 contains a large extracellular N-terminal which consists of five domains, a short transmembrane domain and a small cytoplasmic domain1-3. NRP2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. NRP2 has been shown to mediate proliferation, survival, and migration of tumor cells3.NRP2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous systems2.

Gen-ID: 8828

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals