NPTXR Antikörper (C-Term, Extracellular)

Produktnummer ABIN7885179

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NPTXR in WB, IHC, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für NPTXR Antikörper (C-Term, Extracellular) (ABIN7885179)

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPTXR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-NPTXR Antikörper

Bindungsspezifität: AA 162-176, C-Term, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to NPTXR (extracellular)

Homologie: Rat - identical, human - 14 out of 15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236082)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NPTXR

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Andere Bezeichnung: NPR

Hintergrund:

Synonyms: NPR, NPTXR

Description: Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer's disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.

Gen-ID: 73340

UniProt: Q99J85