Neuroligin 2 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885170

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Neuroligin 2 in WB, IHC, IF, IC und LCI. Es zeigt Reaktivität gegenüber Proben von Ratte und Maus.

Kurzübersicht für Neuroligin 2 Antikörper (Extracellular, N-Term) (ABIN7885170)

Target: Neuroligin 2 (NLGN2)

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuroligin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Neuroligin 2 Antikörper

Bindungsspezifität: AA 657-670, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuroligin 2

Homologie: Mouse - identical, human - 12,14 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat NLGN2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: 1:25

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236052)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Neuroligin 2

Target: Neuroligin 2 (NLGN2)

Andere Bezeichnung: NLGN2

Hintergrund:

Synonyms: NLGN2, NL2

Description: Neuroligins (NLGNs) are a family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners3. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via γ-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing4.Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.

Gen-ID: 117096

UniProt: Q62888

Pathways: Cell-Cell Junction Organization, Synaptic Membrane