Neuroligin 1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885169

Der Kaninchen Polyklonal anti-Neuroligin 1 Antikörper (ABIN7885169) detektiert spezifisch Neuroligin 1 in WB, IHC, IF, IC und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für Neuroligin 1 Antikörper (Extracellular, N-Term) (ABIN7885169)

Target: Neuroligin 1 (NLGN1)

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuroligin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Neuroligin 1 Antikörper

Bindungsspezifität: AA 648-661, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuroligin 1

Homologie: Mouse - identical, human - 13,14 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KVPSTDITLRPTRK, corresponding to amino acid residues 648-661 of rat NLGN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:800

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: 1:300

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236049)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Neuroligin 1

Target: Neuroligin 1 (NLGN1)

Andere Bezeichnung: NLGN1

Hintergrund:

Synonyms: NLGN1, NL1

Description: The NLGN1 gene encodes a member of a family of neuronal cell surface proteins. Neuroligins act as ligands for β-neurexins, cell adhesion proteins located presynaptically. Neuroligin and β-neurexin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neuroligin 1 may be involved in the formation and remodeling of central nervous system synapses1.Proteins of this family may also mediate signaling by recruiting and stabilizing key synaptic components. This is done by interacting with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures1.Mutations in the neuroligin genes are implicated in autism and other cognitive disorders2.Neuroligins have been found to play a role in angiogenesis, specifically in human pheripheral tissues3.Neuroligins bind with the help of Ca2+ to the α-neurexin LNS (laminin, neurexin and sex hormone-binding globulin-like folding units) domains and to the β-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code4. This binding results in a heterotetramer made up of a neuroligin-1 dimer and two neurexin-1 β monomers5.

Gen-ID: 116647

UniProt: Q62765

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis