MT1 Antikörper (3rd Intracellular Loop)

Produktnummer ABIN7885142

Der Kaninchen Polyklonal anti-MT1 Antikörper (ABIN7885142) detektiert spezifisch MT1 in WB, IHC, IC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für MT1 Antikörper (3rd Intracellular Loop) (ABIN7885142)

Target: MT1 (Metallothionein 1 (MT1))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-MT1 Antikörper

Bindungsspezifität: 3rd Intracellular Loop, AA 223-236

Verwendungszweck: A Rabbit Polyclonal Antibody to Melatonin Receptor Type 1A

Homologie: Rat,human - 13,14 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RVKPDNKPKLKPQD, corresponding to amino acid residues 223-236 of mouse MTNR1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235936)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu MT1

Target: MT1 (Metallothionein 1 (MT1))

Andere Bezeichnung: MT1

Hintergrund:

Synonyms: MT1, Mel1a receptor, Mel-1A-R

Description: Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm1-3. Melatonin is also synthesized in the gastrointestinal tract, retina, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli1. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example, anti-stress, sexual dysfunction, obesity, gallbladder stones1,4. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches1.Melatonin exerts its effects through two G-protein coupled receptors (GPCRs), melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-terminal and cytoplasmic C-terminal tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, retina and kidneys and MT2 is expressed in brain and in the retina1.MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the retina and might regulate body temperature1.

Gen-ID: 17773

UniProt: Q61184

Pathways: Transition Metal Ion Homeostasis