LYNX1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885120

Der Kaninchen Polyklonal anti-LYNX1 Antikörper wird verwendet zum Nachweis von LYNX1 in Proben von Maus, Human und Ratte. Er wurde validiert für WB, FACS, IF und IHC.

Kurzübersicht für LYNX1 Antikörper (Extracellular, N-Term) (ABIN7885120)

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LYNX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-LYNX1 Antikörper

Bindungsspezifität: AA 26-38, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Lynx1

Homologie: rat - 12,Mouse,13 amino acid residues identical, human - 11

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235894)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu LYNX1

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Andere Bezeichnung: Ly-6/Neurotoxin-like protein 1

Hintergrund:

Synonyms: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1

Description: Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.

Gen-ID: 23936

UniProt: P0DP60