HRH4 Antikörper (1st Extracellular Loop)

Produktnummer ABIN7885080

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HRH4 in WB, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HRH4 Antikörper (1st Extracellular Loop) (ABIN7885080)

Target: HRH4 (Histamine Receptor H4 (HRH4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRH4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-HRH4 Antikörper

Bindungsspezifität: 1st Extracellular Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to Human Histamine H4 Receptor

Homologie: Won't recognize rat,mouse H4 Histamine Receptor

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: HTLFEWDFGKEIC, corresponding to amino acids 75-87 of human HRH4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu HRH4

Target: HRH4 (Histamine Receptor H4 (HRH4))

Andere Bezeichnung: H4R

Hintergrund:

Synonyms: H4R, HH4R, G-protein coupled receptor 105, GPCR105, GPRv53, AXOR35

Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1- H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Histamine H4 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade.1,2Histamine H4 receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes. H4 receptors modulate eosinophil migration and the selective recruitment of mast cells leading to amplification of histamine-mediated immune responses. In addition, H4 receptors are involved in dendritic cell activation and the regulation of T lymphocyte cytokine production.2,3These studies indicate that histamine H4 receptor is an attractive therapeutic target for the treatment of inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases.2,3

Gen-ID: 59340

UniProt: Q9H3N8