HRH3 Antikörper (3rd Intracellular Loop)

Produktnummer ABIN7885079

Der Kaninchen Polyklonal anti-HRH3 Antikörper (ABIN7885079) detektiert spezifisch HRH3 in WB, IHC, IF und IC. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für HRH3 Antikörper (3rd Intracellular Loop) (ABIN7885079)

Target: HRH3 (Histamine Receptor H3 (HRH3))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Güteklasse: Carrier-free

Produktdetails anti-HRH3 Antikörper

Bindungsspezifität: 3rd Intracellular Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to Histamine H3 Receptor

Homologie: Mouse - identical, human 14,16 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RTRLRLDGGREAGPE, corresponding to amino acids 228-242 of rat HRH3 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235758)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu HRH3

Target: HRH3 (Histamine Receptor H3 (HRH3))

Andere Bezeichnung: H3R

Hintergrund:

Synonyms: H3R, HH3R, GPCR97

Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H3 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, activation of the mitogen-activated protein kinase (MAPK) cascade and inhibition of the Na+/H+ exchanger.1,2H3 receptors are expressed primarily in the central nervous system (CNS) where they are located in presynaptic membranes of histaminergic neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3 receptors are also located on nonhistaminergic neurons, where they regulate the release of other amines such as dopamine, serotonin, and norepinephrine.2,3Based on these studies, a central role for H3 receptors has been proposed in disorders involving cognition such as attention deficit and hyperactivity disorder (ADHD), Alzheimer disease and Schizophrenia, as well as sleep and energy homeostasis (i.e. obesity) disorders.2,3

Gen-ID: 85268

UniProt: Q9QYN8

Pathways: cAMP Metabolic Process, Feeding Behaviour