SH3G2 Antikörper (Intracellular)

Produktnummer ABIN7884928

Der Kaninchen Polyklonal anti-SH3G2 Antikörper wird verwendet zum Nachweis von SH3G2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für SH3G2 Antikörper (Intracellular) (ABIN7884928)

Target: SH3G2 (Endophilin-A1 (SH3G2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH3G2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SH3G2 Antikörper

Bindungsspezifität: AA 255-269, Intracellular

Verwendungszweck: A rabbit polyclonal antibody to Endophilin-A1

Homologie: Rat - identical. Human - 14 out of 15 amino acids identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)YQPKPRMSLEFATGD, corresponding to amino acid residues 255 - 269 of mouse SH3GL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SH3G2

Target: SH3G2 (Endophilin-A1 (SH3G2))

Andere Bezeichnung: SH3GL2

Hintergrund:

Synonyms: SH3 domain-containing GRB2-like protein 2, EEN-B1, SH3 domain protein 2A, SH3GL2

Description:

Endophilin-1 is a member of the Endophilin family, a group of proteins characterized by the presence of BAR (Bin/Amphiphysin/Rvs) and SH3 (Src Homology 3) domains.

The Endophilin family is primarily divided into two subfamilies. Endophilin A , that includes subunits A1, A2 and A3, is predominantly involved in membrane remodeling processes such clathrin-mediated and clathrin-independent endocytic pathways, especially in neurons. The Endophilin B subfamily includes subunits B1 and B2, and is more implicated in mitochondrial dynamics, autophagy and apoptosis.1,2

Endophilin-A1 is expressed almost exclusively in the brain, particularly in synaptic terminals in neurons, consistent with a neuronal specialization for membrane trafficking and synaptic function. It is essential for synaptic vesicle endocytosis, where it recruits and organizes proteins at sites of high membrane curvature to facilitate the formation and recycling of clathrin-coated vesicles at synaptic terminals. It is critical for dendritic spine morphogenesis, synaptic stabilization, and plasticity, supporting both excitatory and inhibitory synaptic organization.3,4

Changes in Endophilin-1 expression are linked to several neurodegenerative disease, most notably, Alzheimer's (AD) and Parkinson disease. Increased expression of Endophilin-1 has been observed in the brains of patients with AD and in transgenic mouse models of the disease.5,6

Endophilin-1 was identified as a Parkinson's disease risk locus and in addition, it was found to be upregulated in a mouse model of the disease.7,8

In summary, Endophilin-A1 not only serves as a compelling target for understanding synaptic biology but also holds promise as a biomarker and therapeutic candidate in neurodegenerative and neuropsychiatric diseases.

Gen-ID: 20404

UniProt: Q62420

Pathways: Neurotrophin Signalübertragung, EGFR Downregulation