DRD5 Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7884921

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DRD5 in WB, IHC, FACS, IF und LCI. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für DRD5 Antikörper (2nd Extracellular Loop) (ABIN7884921)

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DRD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-DRD5 Antikörper

Bindungsspezifität: 2nd Extracellular Loop, AA 199-211

Verwendungszweck: A Rabbit Polyclonal Antibody to D5 Dopamine Receptor

Homologie: Mouse - 12,13 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat DRD5 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235250)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu DRD5

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Andere Bezeichnung: DRD5

Hintergrund:

Synonyms: DRD5, D(1B) dopamine receptor

Description: The D5 dopamine receptor (D5 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1 The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D5 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex, hippocampus and striatum. In the periphery, the D5 receptor has been localized in the adrenal cortex, kidney and intestinal tract.The exact physiological function of the D5 receptor subtype remains poorly understood. Studies with D5 receptor knockout mice have shown no overt alterations in locomotor or cognitive functions. However, knockout mice do develop severe hypertension suggesting a role of the D5 receptor in the modulation of neuronal pathways regulating blood pressure responses.2,3

Gen-ID: 25195

UniProt: P25115

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity