DRD3 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884919

Der Kaninchen Polyklonal anti-DRD3 Antikörper wird verwendet zum Nachweis von DRD3 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, IHC, IF, FACS und LCI.

Kurzübersicht für DRD3 Antikörper (Extracellular, N-Term) (ABIN7884919)

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DRD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free, KO Validated

Produktdetails anti-DRD3 Antikörper

Bindungsspezifität: AA 15-29, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to D3 Dopamine Receptor

Homologie: Mouse - identical, human - 12,15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CGAENSTGVNRARPH, corresponding to amino acid residues 15-29 of rat DRD3 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235243)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu DRD3

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Andere Bezeichnung: DRD3

Hintergrund:

Synonyms: DRD3

Description: The D3 Dopamine Receptor (D3 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D3 receptor distribution in the brain is relatively restricted to limbic areas such as striatum, islands of Calleja and olfactory tubercle. In the periphery, it is expressed in the kidney particularly in proximal tubules.1The exact physiological function of the D3 receptor remains to be fully elucidated. In studies using D3 receptor knockout mice, the most prominent dysfunction was the development of rennin-dependent hypertension. Potential roles in reinforcement and reward behaviors have also been suggested as well as roles in neuropsychiatric disorders such as drug abuse and schizophrenia.2

Gen-ID: 29238

UniProt: P19020

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity