DPP6 Antikörper (C-Term, Extracellular)

Produktnummer ABIN7884911

Der Kaninchen Polyklonal anti-DPP6 Antikörper (ABIN7884911) detektiert spezifisch DPP6 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für DPP6 Antikörper (C-Term, Extracellular) (ABIN7884911)

Target: DPP6 (Dipeptidyl-Peptidase 6 (DPP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-DPP6 Antikörper

Bindungsspezifität: AA 414-426, C-Term, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 6

Homologie: Rat,mouse - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KKHEDESEAWLHR, corresponding to amino acid residues 414-426 of human DPP6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:500

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235207)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu DPP6

Target: DPP6 (Dipeptidyl-Peptidase 6 (DPP6))

Andere Bezeichnung: Dipeptidyl peptidase 6

Hintergrund:

Synonyms: Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2

Description: Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary glycoproteinic subunit of voltage-dependent K+ channel 4 (KV4.x), that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2.DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV - the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1,3.Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4.DPP6 proteins are widely expressed throughout both of the nervous systems - albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5.Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5,6. Endometriosis - a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population - has been linked with DPP6 in genome wide associations studies (GWASs)7.

Gen-ID: 1804

UniProt: P42658