CNTNAP2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7884897

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CNTNAP2 in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für CNTNAP2 Antikörper (C-Term, Intracellular) (ABIN7884897)

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNTNAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-CNTNAP2 Antikörper

Bindungsspezifität: AA 1315-1331, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Caspr2

Homologie: Mouse,rat - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235165)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Andere Bezeichnung: Contactin-associated protein-like 2

Hintergrund:

Synonyms: Contactin-associated protein-like 2, CNTNAP2

Description: Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell-to-cell interactions in the nervous system1,2.Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell-to-cell adhesion complexes via binding to their postsynaptic partners, the neuroligins2.Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels KV1.1, KV1.2, and their cytoplasmic KVβ2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.

Gen-ID: 26047

UniProt: Q9UHC6