Complexin 1 Antikörper (Intracellular, N-Term)

Produktnummer ABIN7884894

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Complexin 1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Complexin 1 Antikörper (Intracellular, N-Term) (ABIN7884894)

Target: Complexin 1 (CPLX1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complexin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-Complexin 1 Antikörper

Bindungsspezifität: AA 14-27, Intracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Complexin-1 and Complexin-2

Homologie: Complexin 1: Mouse,human - identicalComplexin 2: Rat,mouse,human - 13,14 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KDMGKMLGGDEEKD, corresponding to amino acid residues 14-27 of rat Complexin-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Complexin 1

Target: Complexin 1 (CPLX1)

Andere Bezeichnung: Complexin 1

Hintergrund:

Synonyms: Complexin 1, Complexin I, Synaphin-2, Complexin 2, Complexin II, Synaphin-1

Description: Complexins (1 through 4) are small cytosolic proteins that bind tightly to a complex of SNARE proteins to regulate synaptic vesicle membrane fusion via its interaction with synaptotagmin. Complexins activate the quick release of neurotransmitters, triggered by calcium release. They also regulate the "spontaneous release" of neurotransmitters1-3.Complexins are evolutionarily conserved in mammals, Drosophila, and Caenorhabditis elegans1,2. They are divided into four structural domains: flexible N- and C-terminal domains, an accessory domain, and a central α-helical domain. The N-terminal domain plays a role in activation of fast synchronous release in murine neurons and in isolated chromaffin cells. The C-terminal domain binds to phospholipids and is important for regulating spontaneous release in neuronal cultures and suppressing Ca2+-independent fusion in vitro. The accessory domain is necessary for regulating spontaneous release and the central domain is required for all functions1,2.

Gen-ID: 64833, 116657

UniProt: P63041, P84087

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport