CDNF Antikörper (AA 129-141)

Produktnummer ABIN7884856

Der Kaninchen Polyklonal anti-CDNF Antikörper wird verwendet zum Nachweis von CDNF in Proben von Human und Ratte. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für CDNF Antikörper (AA 129-141) (ABIN7884856)

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDNF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-CDNF Antikörper

Bindungsspezifität: AA 129-141

Verwendungszweck: A Rabbit Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor

Homologie: Mouse - 10,13 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EKTLDLASVDLRK, corresponding to amino acid residues 129-141 of human CDNF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:500

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235051)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CDNF

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Andere Bezeichnung: Cerebral dopamine neurotrophic factor

Hintergrund:

Synonyms: Cerebral dopamine neurotrophic factor, Arginine-rich mutated in early stage tumors-like 1, ARMET-like protein 1, ARMETL1

Description: Neurotropic factors (NTFs) comprise an important group of secreted proteins regulating the life cycle of neurons during development. NTFs prevent apoptosis and control the number of neurons innervating a target tissue. NTFs also regulate migration, differentiation and maturation of postmitotic neuronal precursors and promote the regeneration of neurons after injury.Cerebral dopamine neurotrophic factor (CDNF) is a member of a sub-family of NTF proteins. The premature form of the protein consists of 187 amino acids while the mature form contains 161 residues. CDNF has a saposin-like N-terminal domain and an unstructured carboxy C-terminal domain with an intradomain cysteine bridge in a CXXC motif. Notably, saposin-like proteins interact with lipids, suggesting that CDNF's N-terminal may also interact with lipids. The saposin-like domain of CDNF crystalizes as a dimer at pH 4.6. It is presumed that CDNF functions upon synthesis and secretion since it does not contain prosequences for enzymatic activation.When CDNF is injected into the striatum of rats after the injection of 6-OHDA (6-OHDA leads to protracted retrograde degeneration of the nigrostriatal pathway) it significantly reduces amphetamine-induced rotational behavior and protects tyrosine hydroxylase (TH) positive dopaminergic cell bodies in the SN and TH-positive fibers in the striatum. In addition, CDNF had showed neurorestorative effects in the same animal model.Currently it is still unknown if CDNF also affects other types of neurons in the CNS or whether it has any effect on the PNS. It is also not clear to which target molecule CDNF binds and what signaling pathways it activates. CDNF might serve as a therapeutic agent for neurodegenerative diseases1.

Gen-ID: 441549

UniProt: Q49AH0