CABP4 Antikörper (Intracellular)

Produktnummer ABIN7884810

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CABP4 in WB. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für CABP4 Antikörper (Intracellular) (ABIN7884810)

Target: CABP4 (Calcium Binding Protein 4 (CABP4))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CABP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-CABP4 Antikörper

Bindungsspezifität: AA 105-120, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Calcium-Binding Protein 4

Homologie: Rat - identical, human - 14,15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RTYGPLLNRMFGKDR, corresponding to amino acid residues 105-120 of mouse CaBP4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234915)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CABP4

Target: CABP4 (Calcium Binding Protein 4 (CABP4))

Andere Bezeichnung: Calcium-binding protein 4

Hintergrund:

Synonyms: Calcium-binding protein 4

Description: Neuronal calcium-binding proteins (CaBP1-8) belong to a subclass of the calmodulin (CaM) superfamily and regulate in particular Ca2+ channel targets in the brain and retina1.CaBP4 contains two globular domains (N- and C-lobe) that each contains a pair of EF- hand motifs connected by a central linker. The second EF-hand in CaBP4 lacks conserved residues in the binding loop and is predicted to not bind Ca2+. CaBP4 interacts structurally with the C-terminal region of CaV1.4 and this Ca2+-dependent interaction has been implicated in the modulation of voltage-dependent CaV1.4 activation2.Multiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in signal transduction. The CaBP4 isoform regulates voltage-gated Ca2+ channels in retinal photoreceptor cells. In the eye, CaBP4 is localized at the photoreceptor synaptic terminals in rods and cones3. CaBP4 is essential for the development and maintenance of the photoreceptor synapse, likely through functional modulation of the photoreceptor Ca2+ channels, α1F L-type voltage- dependent calcium channels (CaV1.4), and neurotransmitter release4.Mutations in both CaV1.4 and CaBP4 have been identied in patients suffering from congenital stationary night blindness type 2 (CSNB2), indicating that defects in Ca2+-dependent regulation of CaV1.4 by CaBP4 are closely associated with CSNB2. Indeed, deletion of CaBP4 in the mouse leads to a CSNB2-like phenotype5.

Gen-ID: 73660

UniProt: Q8VHC5