CALCRL Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884807

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CALCRL in WB, IHC, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CALCRL Antikörper (Extracellular, N-Term) (ABIN7884807)

Target: CALCRL (Calcitonin Receptor-Like (CALCRL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALCRL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-CALCRL Antikörper

Bindungsspezifität: AA 127-140, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Calcitonin Receptor-Like Receptor

Homologie: Mouse,rat - 12,14 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CNVNTHEKVKTALN, corresponding to amino acid residues 127 - 140 of human Calcitonin Receptor-Like Receptor 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234904)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CALCRL

Target: CALCRL (Calcitonin Receptor-Like (CALCRL))

Andere Bezeichnung: Calcitonin Receptor-Like Receptor

Hintergrund:

Synonyms: Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR

Description: Calcitonin Receptor-Like Receptor 1 (CRLR or CGRPR) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism1.When engaged with its substrate, calcitonin gene related peptide (CGRP), CGRPR activates cAMP-dependent pkA and PI3 kinase, which eventually leads to complex inhibitory as well as facilitator actions on Neuronal Nicotinic Acetylcholine Receptor1.CGRP receptor is a heterodimer composed of two proteins: a 7-transmembrane domain type 2 G-protein coupled receptor called calcitonin-receptor-like receptor (CRLR), and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. RAMP1 serves as a transporter for CRLR to the cell surface and its absence leads to failure of binding with CRLR2.CGRP and CGRPR are ubiquitously expressed and their interaction is related to various diseases and health states such as migraines3 and Alzheimer's disease1.

Gen-ID: 10203

UniProt: Q16602

Pathways: cAMP Metabolic Process