Cadherin 13 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884804

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Cadherin 13 in WB und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Cadherin 13 Antikörper (Extracellular, N-Term) (ABIN7884804)

Target: Cadherin 13 (CDH13)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cadherin 13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Cadherin 13 Antikörper

Bindungsspezifität: AA 164-178, Extracellular, N-Term

Verwendungszweck: A rabbit polyclonal antibody to Cadherin-13 (extracellular)

Homologie: Rat - identical.  Human - 14 out of 15 amino acid residues identical.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DSDRPEGSKFRLTGK, corresponding to amino acid residues 164 - 178 of mouse CDH13

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Cadherin 13

Target: Cadherin 13 (CDH13)

Andere Bezeichnung: CDH13

Hintergrund:

Synonyms: CDH13, Heart Cadherin, H-Cadherin, Truncated Cadherin, T-Cadherin, T-Cad

Description:

Cadherin-13 (CDH13), also known as Heart Cadherin (H-Cadherin) or Truncated Cadherin (T-cadherin), is a member of the cadherin superfamily, a group of calcium-dependent cell adhesion molecules integral to various cellular processes, including tissue development and maintenance.1

Unlike classical cadherins, which are type I membrane proteins that span the cell membrane once, Cadherin-13 is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI)-anchor, making it an atypical cadherin.1,2

Cadherin-13 is predominantly expressed in the nervous system, where it regulates neuronal migration, axon growth, and synaptic connectivity during brain development. It mediates cell adhesion through homophilic interactions, meaning it binds to other Cadherin-13 Molecules on adjacent cells. This adhesive property is crucial for maintaining the structural integrity of neural circuits and facilitating proper brain function.2,3

Alterations in Cadherin-13 expression or function have been linked to various neurodevelopmental and psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and schizophrenia. These associations underscore the critical role of Cadherin-13 in brain function and behavior.3,4

Beyond the nervous system, Cadherin-13 has been implicated in metabolic regulation. It serves as a binding protein for high molecular weight isoforms of adiponectin, an adipose-derived hormone with anti-inflammatory and insulin-sensitizing properties. This interaction is essential for mediating adiponectin's effects on metabolic processes and vascular function.3,5,6

Finally, Cadherin-13 expression is often downregulated in various cancers, including colon and prostate cancers. This downregulation is associated with increased invasive and metastatic potential of tumor cells and poorer prognosis, indicating that Cadherin-13 may function as a tumor suppressor.7

Gen-ID: 12554

UniProt: Q9WTR5

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization