AQP11 Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7884764

Der Kaninchen Polyklonal anti-AQP11 Antikörper (ABIN7884764) detektiert spezifisch AQP11 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Ratte.

Kurzübersicht für AQP11 Antikörper (2nd Extracellular Loop) (ABIN7884764)

Target: AQP11 (Aquaporin 11 (AQP11))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AQP11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-AQP11 Antikörper

Bindungsspezifität: 2nd Extracellular Loop, AA 140-151

Verwendungszweck: A Rabbit Polyclonal Antibody to Aquaporin 11 Channel

Homologie: Mouse - 11,12 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)SLSLTKYHFDER, corresponding to amino acid residues 140-151 of rat AQP11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:1000

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234755)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu AQP11

Target: AQP11 (Aquaporin 11 (AQP11))

Andere Bezeichnung: AQP11

Hintergrund:

Synonyms: AQP11

Description: The aquaporins (AQP), also known as the major intrinsic protein superfamily (MIP), are a family of integral membrane proteins. In mammals, 13 aquaporins were described (AQP0-AQP12). Aquaporin 11 (AQP11) is a newly described member of the aquaporins family. Aquaporin 11 (AQP11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes. AQP11 presents a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1. There are two subfamilies: the aquaporins, which transport only water and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water2.Aquaporins and aquaglyceroporins are ubiquitously expressed, including in the plasma membrane of renal epithelia, brain astrocytes, and red blood cells3. AQP11 is expressed in several tissues including testis, kidney, liver, and brain. In the brain, AQP11 is found in Purkinje cells, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons4. In the kidney AQP11 has a central role in vesicular homeostasis as demonstrated in experiments using AQP11 knockout mice which display growth retardation and progressively die before weaning. The cause of death seems to be advanced renal failure5.

Gen-ID: 286758

UniProt: Q8CHM1