Anoctamin 2 Antikörper (3rd Extracellular Loop)

Produktnummer ABIN7884759

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Anoctamin 2 in WB, IHC, IF und IC. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für Anoctamin 2 Antikörper (3rd Extracellular Loop) (ABIN7884759)

Target: Anoctamin 2 (ANO2)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Anoctamin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Güteklasse: Carrier-free, KO Validated

Produktdetails anti-Anoctamin 2 Antikörper

Bindungsspezifität: 3rd Extracellular Loop, AA 632-646

Verwendungszweck: A Rabbit Polyclonal Antibody to Anoctamin-2 (TMEM16B) Channel

Homologie: human - 13,Rat - 14,15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)HSKRPEQWDLDHSLE, corresponding to amino acid residues 632-646 of mouse Anoctamin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7234739)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Anoctamin 2

Target: Anoctamin 2 (ANO2)

Andere Bezeichnung: Anoctamin-2

Hintergrund:

Synonyms: Anoctamin-2, Transmembrane protein 16B, C12orf3

Description: Anoctamin (ANO or TMEM16) is a family of 10 membrane proteins. This family is named so because these channels are selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini1. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants and yeast1. Alternative splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize2.Ano1 (or TMEM16A, DOG1 and others) the first member to be identified was found to be a Ca2+-activated Cl- channel3-5 therefore other members are likely to also be Cl- channels. These channels are expressed in many different tissues: bronchiolar epithelial cells, pancreatic acinar cells, proximal kidney tubule epithelium, retina, dorsal root ganglia and submandibular gland1. In fact, Ano1 gained a lot of attention as its activation may serve as a therapeutic treatment for cystic fibrosis since it is also expressed in the airways6. These Ca2+-activated Cl- channels are believed to play a role in development as knockout of Ano1 in mice causes abnormal development of the trachea7. Ano2 (TMEM16B) has been shown to mediate Ca2+-activated Cl- current in olfactory epithelium and photoreceptor synapses2,8,9.Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestinal tumors as its expression is significantly upregulated10,11. Similarly, Ano1 is also highly expressed in other carcinomas12,13.

Gen-ID: 243634

UniProt: Q8CFW1