Vitronectin Receptor Antikörper

Produktnummer ABIN7882687

Der Maus Monoklonal anti-Vitronectin Receptor Antikörper wird verwendet zum Nachweis von Vitronectin Receptor in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für Vitronectin Receptor Antikörper (ABIN7882687)

Target: Vitronectin Receptor

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 23C6

Produktdetails

Verwendungszweck: Vitronectin Receptor Antibody / Integrin alpha V / ITGAV (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Osteoclasts from osteoclastomas were used as the immunogen for the Vitronectin Receptor antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Vitronectin Receptor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Vitronectin Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: Vitronectin Receptor

Hintergrund: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

UniProt: P06756