Troponin I Antikörper

Produktnummer ABIN7882571

Der Kaninchen Polyklonal anti-Troponin I Antikörper (ABIN7882571) detektiert spezifisch Troponin I in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für Troponin I Antikörper (ABIN7882571)

Target: Troponin I (TNNI)

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Troponin I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Troponin I Antikörper

Verwendungszweck: Troponin I Antibody / TNNI3

Sequenz: MMQALLGARA KESLDLRAHL KQ

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids MMQALLGARAKESLDLRAHLKQ were used as the immunogen for the Troponin I antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Troponin I antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Troponin I antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Troponin I

Target: Troponin I (TNNI)

Andere Bezeichnung: Troponin I

Hintergrund: Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

UniProt: P19429