Rekombinanter TMEM67 Antikörper

Produktnummer ABIN7882553

Der Kaninchen Monoklonal anti-TMEM67 Antikörper (Klon 30T77) (ABIN7882553) detektiert spezifisch TMEM67 in WB, IF, IHC, FACS und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter TMEM67 Antikörper (ABIN7882553)

Target: TMEM67 (Transmembrane Protein 67 (TMEM67))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TMEM67 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 30T77

Produktdetails anti-TMEM67 Antikörper

Verwendungszweck: TMEM67 Antibody / Meckelin

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Meckelin was used as the immunogen for the TMEM67 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TMEM67 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the TMEM67 antibody at -20oC.

Details zu TMEM67

Target: TMEM67 (Transmembrane Protein 67 (TMEM67))

Andere Bezeichnung: TMEM67

Hintergrund: TMEM67 antibody detects meckelin, a transmembrane protein encoded by the TMEM67 gene. Meckelin localizes to primary cilia and the plasma membrane, where it contributes to ciliary structure and signaling. Mutations in TMEM67 cause Meckel syndrome type 3 and Joubert syndrome type 6, autosomal recessive ciliopathies characterized by developmental abnormalities, cystic kidneys, and neurological defects. Meckelin is therefore essential for cilia based signaling pathways, including Wnt and Hedgehog.

TMEM67 antibody is widely applied in developmental biology, nephrology, and neurogenetics. By detecting meckelin, researchers can study how ciliary proteins regulate organ development and signaling. Ciliary dysfunction underlies a spectrum of disorders known as ciliopathies, linking TMEM67 research to human disease mechanisms.

Western blot assays detect meckelin in tissue lysates, while immunohistochemistry maps expression in kidney, brain, and liver. Immunofluorescence highlights punctate staining at primary cilia, consistent with its functional localization. These applications provide robust tools for examining ciliary protein biology.

Meckelin plays roles in regulating planar cell polarity, neuronal migration, and renal morphogenesis. Its dysfunction disrupts signaling and tissue organization, causing developmental defects and organ pathology. By applying TMEM67 antibody, scientists can investigate pathways linking ciliary function to embryogenesis, neurodevelopment, and kidney disease.

TMEM67 antibody from NSJ Bioreagents delivers dependable specificity for studying meckelin function. Its strong performance ensures accurate detection across developmental and disease contexts.

UniProt: Q5HYA8