Rekombinanter TIMM44 Antikörper

Produktnummer ABIN7882540

Der Kaninchen Monoklonal anti-TIMM44 Antikörper wird verwendet zum Nachweis von TIMM44 in Proben von Human und Ratte. Er wurde validiert für WB, IF, ICC, IP und FACS.

Kurzübersicht für Rekombinanter TIMM44 Antikörper (ABIN7882540)

Target: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TIMM44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS)

Klon: 30T70

Produktdetails anti-TIMM44 Antikörper

Verwendungszweck: TIMM44 Antibody / Translocase of inner mitochondrial membrane 44

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TIM44 was used as the immunogen for the TIMM44 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TIMM44 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the TIMM44 antibody at -20oC.

Details zu TIMM44

Target: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Andere Bezeichnung: TIMM44

Hintergrund: TIM44 antibody recognizes translocase of inner mitochondrial membrane 44, a central component of the mitochondrial protein import machinery. TIM44 anchors mitochondrial Hsp70 to the inner membrane, enabling preprotein translocation through the TIM23 complex. By facilitating proper protein targeting, TIM44 ensures mitochondrial biogenesis and maintenance of energy production.

Research using TIM44 antibody has highlighted its importance in mitochondrial function and human disease. Altered expression of TIM44 can impair protein import, leading to mitochondrial stress and metabolic dysfunction. Dysregulation has been linked to neurodegenerative conditions, where defective energy metabolism is a hallmark, and to metabolic syndromes associated with impaired mitochondrial quality control.

Validated clones for TIM44 detection are suitable for western blot, immunofluorescence, and immunohistochemistry. These reagents allow investigators to track mitochondrial protein import efficiency and examine changes in response to cellular stress. Monitoring TIM44 levels provides valuable insight into how cells adapt to demands on mitochondrial biogenesis and oxidative metabolism.

NSJ Bioreagents offers this TIM44 antibody to support studies in mitochondrial biology, metabolic regulation, and disease. Alternate names include translocase of inner mitochondrial membrane 44 antibody, mitochondrial import receptor subunit TIM44 antibody, and HSP-binding protein antibody.

UniProt: O43615