Rekombinanter TIMM22 Antikörper

Produktnummer ABIN7882539

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch TIMM22 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter TIMM22 Antikörper (ABIN7882539)

Target: TIMM22 (Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TIMM22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 31T40

Produktdetails anti-TIMM22 Antikörper

Verwendungszweck: TIMM22 Antibody / Translocase of inner mitochondrial membrane 22

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TIMM22 was used as the immunogen for the TIMM22 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TIMM22 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the TIMM22 antibody at -20oC.

Details zu TIMM22

Target: TIMM22 (Translocase of Inner Mitochondrial Membrane 22 Homolog (TIMM22))

Andere Bezeichnung: TIMM22

Hintergrund: TIMM22 antibody detects translocase of inner mitochondrial membrane 22, a mitochondrial import protein encoded by the TIMM22 gene. TIMM22 is part of the TIM22 complex, which mediates insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It recognizes hydrophobic precursor proteins delivered by the small TIM chaperone complex and inserts them into the inner membrane in an energy-dependent process. Through this activity, TIMM22 ensures proper biogenesis of mitochondrial carriers and maintenance of energy metabolism.

TIMM22 antibody is widely applied in mitochondrial biology and protein trafficking research. By detecting TIMM22, scientists can study how mitochondrial import machinery regulates oxidative phosphorylation and cellular energy production. Defects in TIMM22 function lead to impaired assembly of carrier proteins such as ADP/ATP translocases, disrupting mitochondrial function and cellular homeostasis.

Western blot assays detect TIMM22 protein in mitochondrial fractions, while immunohistochemistry highlights expression in tissues with high metabolic demand such as muscle, heart, and brain. Immunofluorescence reveals punctate mitochondrial staining, consistent with its localization in the inner membrane. These methods allow precise analysis of mitochondrial import processes.

Mutations in TIMM22 and disruption of mitochondrial protein import are linked to metabolic disorders, neurodegeneration, and cardiomyopathy. By applying TIMM22 antibody, researchers can investigate how defects in import machinery contribute to disease and explore therapeutic strategies to restore mitochondrial function.

TIMM22 antibody from NSJ Bioreagents provides dependable specificity for studying mitochondrial protein import and energy metabolism. Its strong performance across applications ensures accurate detection of TIMM22 in diverse biological systems.

UniProt: Q9Y584