Rekombinanter TSH receptor Antikörper

Produktnummer ABIN7882481

Der Kaninchen Monoklonal anti-TSH receptor Antikörper (Klon TSHRB-1607R) (ABIN7882481) detektiert spezifisch TSH receptor in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter TSH receptor Antikörper (ABIN7882481)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TSH receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TSHRB-1607R

Produktdetails anti-TSH receptor Antikörper

Verwendungszweck: Recombinant TSH Receptor Antibody / B-Chain (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant human TSHR B-Chain protein was used as the immunogen for the recombinant TSH Receptor antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant TSH Receptor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant TSH Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Andere Bezeichnung: TSH Receptor

Hintergrund: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

UniProt: P16473

Pathways: Thyroid Hormone Synthesis