Rekombinanter TAO Kinase 1 (TAOK1) Antikörper

Produktnummer ABIN7882426

Der Kaninchen Monoklonal anti-TAO Kinase 1 Antikörper wird verwendet zum Nachweis von TAO Kinase 1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter TAO Kinase 1 (TAOK1) Antikörper (ABIN7882426)

Target: TAO Kinase 1 (TAOK1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Klon: 30T29

Produktdetails

Verwendungszweck: TAOK1 Antibody / Thousand and one amino acid protein kinase 1

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TAOK1 was used as the immunogen for the TAOK1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TAOK1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the TAOK1 antibody at -20oC.

Antigendetails

Target: TAO Kinase 1 (TAOK1)

Andere Bezeichnung: TAOK1

Hintergrund: TAOK1 antibody detects thousand and one amino acid protein kinase 1, a serine threonine kinase encoded by the TAOK1 gene. TAOK1 belongs to the MAP kinase kinase kinase family and regulates diverse cellular processes including cytoskeletal organization, stress signaling, and apoptosis. Through phosphorylation of downstream MAP kinases, TAOK1 influences cell cycle progression and response to environmental stress.

TAOK1 antibody is widely used in studies of kinase signaling, neuronal development, and cancer biology. In neurons, TAOK1 has been linked to axon outgrowth, dendritic branching, and synaptic plasticity. Mutations and altered expression of TAOK1 have been implicated in neurodevelopmental disorders including autism spectrum disorder. By detecting TAOK1, researchers can evaluate how changes in kinase signaling contribute to brain development and function.

The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect bands corresponding to TAOK1 isoforms across different tissues. Immunohistochemistry highlights expression in developing brain regions, while immunofluorescence provides subcellular localization at cytoskeletal structures and kinases in signaling complexes.

TAOK1 also regulates apoptotic pathways through activation of stress activated protein kinases. It contributes to programmed cell death under stress conditions, linking it to cancer and degenerative disease. Elevated TAOK1 expression has been reported in tumors, where it may affect proliferation and survival pathways. By applying TAOK1 antibody, scientists can study its role in balancing survival and death signals in health and disease.

TAOK1 antibody from NSJ Bioreagents offers dependable specificity for analyzing MAP kinase signaling, neuronal development, and oncogenesis. Its performance across applications makes it a valuable reagent for laboratories studying cellular stress responses and growth regulation.

UniProt: Q7L7X3