Rekombinanter SNX5 Antikörper

Produktnummer ABIN7882339

Der Kaninchen Monoklonal anti-SNX5 Antikörper wird verwendet zum Nachweis von SNX5 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, IF und ICC.

Kurzübersicht für Rekombinanter SNX5 Antikörper (ABIN7882339)

Target: SNX5 (Sorting Nexin 5 (SNX5))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SNX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 30S11

Produktdetails anti-SNX5 Antikörper

Verwendungszweck: SNX5 Antibody / Sorting nexin 5

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human SNX5 was used as the immunogen for the SNX5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SNX5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the SNX5 antibody at -20oC.

Details zu SNX5

Target: SNX5 (Sorting Nexin 5 (SNX5))

Andere Bezeichnung: SNX5

Hintergrund: SNX5 antibody detects sorting nexin 5, a member of the sorting nexin family that regulates endosomal trafficking and membrane remodeling. SNX5 contains a phox homology (PX) domain, which binds phosphoinositides on endosomal membranes, and a BAR domain, which promotes membrane curvature and tubulation. Together, these domains allow SNX5 to coordinate cargo retrieval from endosomes and direct proteins to specific intracellular destinations.

Research using SNX5 antibody has shown that SNX5 participates in the retromer complex, where it cooperates with other sorting nexins such as SNX1 and SNX2 to mediate retrograde transport of receptors and enzymes. Disruption of SNX5 function impairs recycling of critical cargo such as cation-independent mannose-6-phosphate receptors, affecting lysosomal enzyme trafficking. These defects can contribute to lysosomal storage disorders and cellular stress responses.

SNX5 has also been linked to viral infection and cancer biology. Certain viruses exploit SNX5-mediated endosomal pathways to promote entry and replication, while altered expression of SNX5 in cancer may influence cell signaling, proliferation, and migration. Its role in trafficking growth factor receptors underscores its significance in tumor biology. In immune cells, SNX5 contributes to antigen presentation by regulating transport of major histocompatibility complex molecules.

Antibodies against SNX5 are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable analysis of protein expression, intracellular localization, and retromer function. Clone-based antibodies ensure specificity, distinguishing SNX5 from other sorting nexins with overlapping roles.

NSJ Bioreagents provides this SNX5 antibody to support studies in endosomal trafficking, retromer biology, and disease pathways.

UniProt: Q9Y5X3