Rekombinanter RAPGEF4 Antikörper

Produktnummer ABIN7882136

Der Kaninchen Monoklonal anti-RAPGEF4 Antikörper (Klon 22R17) (ABIN7882136) detektiert spezifisch RAPGEF4 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter RAPGEF4 Antikörper (ABIN7882136)

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RAPGEF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 22R17

Produktdetails anti-RAPGEF4 Antikörper

Verwendungszweck: RAPGEF4 Antibody / EPAC 2

Aufreinigung: Affinity chromatography

Immunogen: A peptide sequence specific to Rap guanine nucleotide exchange factor 4 protein was used as the immunogen for the RAPGEF4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RAPGEF4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RAPGEF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RAPGEF4

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Andere Bezeichnung: RAPGEF4

Hintergrund: Rap guanine nucleotide exchange factor 4 (RAPGEF4), also known as EPAC 2 (Exchange protein directly activated by cAMP 2), is a cAMP-regulated guanine nucleotide exchange factor that activates Rap1 and Rap2 small GTPases. Unlike protein kinase A, RAPGEF4 mediates cAMP signaling through a PKA-independent pathway, influencing processes such as cell adhesion, insulin secretion, and synaptic plasticity.

RAPGEF4 is expressed predominantly in the brain and endocrine tissues, where it contributes to learning and memory, hormone release, and neuronal signaling. Altered RAPGEF4 function has been implicated in metabolic disorders, neuropsychiatric conditions, and cancer, making it a significant target for biomedical research.

Using a high-quality RAPGEF4 antibody allows for sensitive detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A RAPGEF4 antibody from NSJ Bioreagents ensures reliable and reproducible performance for studies in cAMP signaling, neuronal function, and endocrine regulation. Selecting the right RAPGEF4 antibody is essential for achieving accurate and consistent experimental results.

UniProt: Q8WZA2

Pathways: Hormone Transport, Smooth Muscle Cell Migration