POGLUT1 Antikörper

Produktnummer ABIN7882078

Der Kaninchen Polyklonal anti-POGLUT1 Antikörper wird verwendet zum Nachweis von POGLUT1 in Proben von Human und Maus. Er wurde validiert für WB, IF und IHC (p).

Kurzübersicht für POGLUT1 Antikörper (ABIN7882078)

Target: POGLUT1 (Protein O-Glucosyltransferase 1 (POGLUT1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POGLUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-POGLUT1 Antikörper

Verwendungszweck: POGLUT1 Antibody / CLP46 / Rumi

Sequenz: KTDLSNVQEL LQFVKANDDV AQEIAER

Aufreinigung: Affinity purified

Immunogen: Amino acids KTDLSNVQELLQFVKANDDVAQEIAER from the human protein were used as the immunogen for the POGLUT1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the POGLUT1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the POGLUT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu POGLUT1

Target: POGLUT1 (Protein O-Glucosyltransferase 1 (POGLUT1))

Andere Bezeichnung: POGLUT1

Hintergrund: This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants.

UniProt: Q8NBL1

Pathways: Notch Signalweg