Rekombinanter PREPL Antikörper

Produktnummer ABIN7882049

Der Kaninchen Monoklonal anti-PREPL Antikörper (Klon 30P78) (ABIN7882049) detektiert spezifisch PREPL in WB, IF, ICC, IP und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter PREPL Antikörper (ABIN7882049)

Target: PREPL (Prolyl Endopeptidase Like Protein (PREPL))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PREPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS)

Klon: 30P78

Produktdetails anti-PREPL Antikörper

Verwendungszweck: PREPL Antibody / Prolyl endopeptidase-like protein

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PREPL was used as the immunogen for the PREPL antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PREPL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the PREPL antibody at -20oC.

Details zu PREPL

Target: PREPL (Prolyl Endopeptidase Like Protein (PREPL))

Andere Bezeichnung: PREPL

Hintergrund: PREPL antibody detects prolyl endopeptidase-like protein, a cytosolic serine peptidase of the prolyl oligopeptidase family. Unlike other family members, PREPL lacks proteolytic activity due to an inactive catalytic triad, but it retains structural features of peptidases. PREPL is expressed widely, with high levels in brain, kidney, and skeletal muscle, and contributes to intracellular peptide processing, protein-protein interactions, and vesicular trafficking.

Research using PREPL antibody has connected the protein to congenital and neurological disorders. Homozygous deletions affecting PREPL cause hypotonia-cystinuria syndrome, a rare genetic condition characterized by severe neonatal hypotonia, growth retardation, cystinuria, and dysmorphic features. The disorder highlights PREPL's importance in neuromuscular function and metabolic regulation. Additional studies suggest PREPL contributes to vesicle-mediated release of neurotransmitters and hormones, implicating it in neuroendocrine regulation.

Functional studies in animal models have revealed that PREPL knockout mice exhibit growth retardation, motor abnormalities, and altered metabolic phenotypes, consistent with findings in human patients. PREPL has also been implicated in skeletal muscle function, further supporting its role in neuromuscular biology.

PREPL has emerging links to cancer and metabolic disease. Abnormal expression has been detected in certain tumors, although its precise role remains under investigation. Its involvement in vesicular trafficking and peptide regulation suggests PREPL may influence signaling pathways related to growth and proliferation.

Antibodies against PREPL are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents enable reliable detection of PREPL in tissue and cell-based studies, supporting research into peptide regulation, vesicular biology, and neuromuscular disease. Clone-based antibodies provide specificity required for reproducibility in complex biological samples.

NSJ Bioreagents supplies this PREPL antibody for research on congenital disease, metabolism, and neurobiology.

UniProt: Q4J6C6