Rekombinanter PREB Antikörper

Produktnummer ABIN7882037

Der Kaninchen Monoklonal anti-PREB Antikörper (Klon 29P71) (ABIN7882037) detektiert spezifisch PREB in WB, IHC, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter PREB Antikörper (ABIN7882037)

Target: PREB (Prolactin Regulatory Element Binding (PREB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PREB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 29P71

Produktdetails anti-PREB Antikörper

Verwendungszweck: PREB Antibody / Prolactin regulatory element binding protein

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PREB was used as the immunogen for the PREB antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PREB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the PREB antibody at -20oC.

Details zu PREB

Target: PREB (Prolactin Regulatory Element Binding (PREB))

Andere Bezeichnung: PREB

Hintergrund: PREB antibody detects prolactin regulatory element binding protein, a transcription factor involved in gene regulation and vesicular trafficking. PREB contains WD-repeat domains that facilitate protein-protein interactions, allowing it to function as a transcriptional regulator and vesicle-associated factor. It is expressed in a variety of tissues, with high levels in brain, pituitary, and pancreas, underscoring its multifunctional roles in development and physiology.

Research using PREB antibody has revealed two primary functions of the protein. First, PREB binds to promoter elements of the prolactin gene, regulating hormone expression in the anterior pituitary. By influencing prolactin secretion, PREB impacts reproductive biology, lactation, and endocrine homeostasis. Second, PREB is associated with vesicular transport machinery, where it facilitates protein trafficking between the endoplasmic reticulum and Golgi apparatus. This dual role positions PREB as a regulator of both transcription and intracellular trafficking.

In developmental biology, PREB has been shown to be essential for embryogenesis and organogenesis. Knockout models reveal that PREB deficiency leads to embryonic lethality, indicating its necessity for proper gene regulation and cellular organization. Heterozygous models display neurological and metabolic abnormalities, linking PREB to central nervous system development and energy balance.

PREB has also been studied in the context of neurological and metabolic disorders. Altered PREB expression affects neuroendocrine regulation and insulin secretion. Dysregulation of vesicular trafficking involving PREB has implications for protein misfolding diseases and diabetes. In cancer research, PREB expression changes have been linked to tumor progression, although its exact role remains under investigation.

Antibodies against PREB are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to study nuclear localization, promoter occupancy, and trafficking-related functions. Clone-based antibodies ensure specificity and reproducibility across experimental systems.

NSJ Bioreagents supplies this PREB antibody for research into transcriptional regulation, neuroendocrine biology, and vesicular trafficking.

UniProt: Q9HCU5

Pathways: ER-Nucleus Signaling