Rekombinanter PCBP2 Antikörper

Produktnummer ABIN7881993

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch PCBP2 in WB, IF, ICC und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter PCBP2 Antikörper (ABIN7881993)

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PCBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Klon: 30P20

Produktdetails anti-PCBP2 Antikörper

Verwendungszweck: PCBP2 Antibody / Poly(rC)-binding protein 2

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PCBP2 was used as the immunogen for the PCBP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PCBP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the PCBP2 antibody at -20oC.

Details zu PCBP2

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Andere Bezeichnung: PCBP2

Hintergrund: PCBP2 antibody detects poly(rC)-binding protein 2, an RNA-binding protein that regulates mRNA stability, translation, and alternative splicing. PCBP2 belongs to the heterogeneous nuclear ribonucleoprotein K-homology domain family and binds poly(C)-rich RNA sequences, influencing post-transcriptional control of numerous transcripts. PCBP2 is widely expressed and has essential functions in iron metabolism, viral replication, and gene expression regulation.

Research using PCBP2 antibody has revealed the protein's multifunctional nature. In iron homeostasis, PCBP2 acts as a cytosolic iron chaperone, delivering iron to ferritin for storage and supporting enzymatic cofactors. Its role in viral biology is equally significant: PCBP2 has been shown to bind viral RNA, regulating replication of poliovirus, hepatitis C virus, and enteroviruses. In addition, PCBP2 can function as a negative regulator of antiviral signaling, making it an attractive target in infection research.

In cancer, PCBP2 expression is frequently dysregulated. Overexpression can promote tumorigenesis by stabilizing oncogenic transcripts and influencing signaling pathways. Conversely, loss of PCBP2 disrupts iron metabolism and RNA processing, contributing to genomic instability. Its widespread regulatory functions make it relevant for studies across oncology, virology, and metabolism.

Antibodies against PCBP2 are validated for western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry. These tools allow researchers to examine PCBP2's role in RNA binding, protein interactions, and cellular localization. Clone-based antibodies ensure reliable specificity when distinguishing PCBP2 from other PCBP family members.

NSJ Bioreagents offers this PCBP2 antibody for research in RNA biology, viral replication, and cancer.

UniProt: Q15366