Rekombinanter Nucleolin Antikörper

Produktnummer ABIN7881852

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Nucleolin in WB, IHC, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter Nucleolin Antikörper (ABIN7881852)

Target: Nucleolin (NCL)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Nucleolin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 30N86

Produktdetails anti-Nucleolin Antikörper

Verwendungszweck: NCL Antibody / Nucleolin

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Nucleolin was used as the immunogen for the NCL antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NCL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the NCL antibody at -20oC.

Details zu Nucleolin

Target: Nucleolin (NCL)

Andere Bezeichnung: NCL

Hintergrund: NCL antibody detects nucleolin, a multifunctional nucleolar protein involved in ribosome biogenesis, RNA metabolism, and chromatin organization. Nucleolin is one of the most abundant nucleolar proteins, shuttling between the nucleolus, nucleoplasm, and cytoplasm. Its diverse functions include rRNA transcription, processing, and ribosomal subunit assembly, making it essential for protein synthesis. In addition, nucleolin participates in mRNA stabilization, DNA repair, and chromatin remodeling.

Research using NCL antibody has shown that nucleolin plays crucial roles in cell proliferation and stress responses. Because of its involvement in ribosome production, nucleolin is highly expressed in rapidly dividing cells. In cancer, overexpression of NCL promotes tumor growth, angiogenesis, and resistance to apoptosis. Nucleolin interacts with oncogenic and tumor suppressor pathways, making it both a biomarker and potential therapeutic target.

In addition to cancer, nucleolin is implicated in viral infection, neurodegeneration, and cardiovascular disease. Viruses such as HIV and SARS-CoV-2 exploit nucleolin for entry or replication. In neurobiology, nucleolin regulates synaptic plasticity and neuronal survival under stress conditions. In cardiology, nucleolin modulates stress signaling pathways and contributes to vascular remodeling.

Nucleolin is also a target for therapeutic development. Aptamers, peptides, and small molecules targeting NCL are being explored in oncology and antiviral research. Monitoring NCL expression with antibodies helps evaluate disease progression and therapeutic efficacy.

Antibodies against nucleolin are validated for western blot, immunohistochemistry, immunofluorescence, and ELISA. These reagents provide robust detection across tissues and experimental systems. Clone-based NCL antibodies ensure specificity, supporting reproducible research outcomes.

NSJ Bioreagents provides this NCL antibody for studies in cancer, virology, and cellular stress biology.

UniProt: P19338

Pathways: Ribonucleoprotein Complex Subunit Organization