Rekombinanter KLC3 Antikörper

Produktnummer ABIN7881445

Der Kaninchen Monoklonal anti-KLC3 Antikörper wird verwendet zum Nachweis von KLC3 in Proben von Human und Maus. Er wurde validiert für WB, FACS, IHC, ICC, IF und IP.

Kurzübersicht für Rekombinanter KLC3 Antikörper (ABIN7881445)

Target: KLC3 (Kinesin Light Chain 3 (KLC3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser KLC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 32K83

Produktdetails anti-KLC3 Antikörper

Verwendungszweck: KLC3 Antibody / Kinesin light chain 3

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human KLC3 was used as the immunogen for the KLC3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the KLC3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the KLC3 antibody at -20oC.

Details zu KLC3

Target: KLC3 (Kinesin Light Chain 3 (KLC3))

Andere Bezeichnung: KLC3

Hintergrund: KLC3 antibody detects kinesin light chain 3, a subunit of the kinesin-1 Molecular motor complex responsible for microtubule-based transport. KLC proteins function as adaptors, linking cargo vesicles and organelles to kinesin heavy chains for movement toward the plus-end of microtubules. KLC3 is primarily expressed in testis and has unique roles in spermatogenesis, where it regulates transport of mitochondria and other organelles during sperm tail development.

Research using KLC3 antibody has shown that loss or dysfunction of KLC3 impairs mitochondrial localization in sperm flagella, leading to defective motility and male infertility. In animal models, KLC3 knockout results in abnormal sperm morphology and reduced fertility, confirming its importance for reproductive biology. Beyond reproduction, kinesin light chains also participate in neuronal transport, suggesting that KLC3 may share overlapping functions with other KLC isoforms in cargo regulation.

Aberrant regulation of kinesin proteins, including KLC3, has been linked to neurodegenerative disease and cancer. Disruption of intracellular transport contributes to neuronal dysfunction in disorders such as Alzheimer's disease, while tumor cells often exploit vesicle trafficking for signaling and survival. Studying KLC3 expression therefore offers insight into both specialized reproductive roles and broader cell biological processes.

Antibodies against KLC3 are validated for applications such as western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to examine protein expression patterns, subcellular localization, and cargo-binding dynamics. Clone-based antibodies ensure high specificity when distinguishing KLC3 from closely related family members such as KLC1 and KLC2.

NSJ Bioreagents provides this KLC3 antibody for research in reproduction, intracellular trafficking, and disease pathways linked to motor protein function.

UniProt: Q6P597