Rekombinanter INMT Antikörper

Produktnummer ABIN7881168

Der Kaninchen Monoklonal anti-INMT Antikörper wird verwendet zum Nachweis von INMT in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter INMT Antikörper (ABIN7881168)

Target: INMT (Indolethylamine N-Methyltransferase (INMT))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser INMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 29I89

Produktdetails anti-INMT Antikörper

Verwendungszweck: INMT Antibody / TEMT

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TEMT was used as the immunogen for the INMT antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the INMT antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the INMT antibody at -20oC.

Details zu INMT

Target: INMT (Indolethylamine N-Methyltransferase (INMT))

Andere Bezeichnung: INMT

Hintergrund: INMT antibody detects indolethylamine N methyltransferase, also known as TEMT, encoded by the INMT gene. INMT is a cytosolic enzyme that catalyzes the N methylation of tryptamine and other indolethylamines, producing N N dimethyltryptamine and related metabolites. This activity places INMT in pathways regulating biogenic amine metabolism, neurotransmitter balance, and endogenous hallucinogen production. INMT is expressed in liver, lung, brain, and peripheral tissues, suggesting roles in both metabolic clearance and neuroregulation.

INMT antibody is widely applied in neurobiology, pharmacology, and metabolism research. INMT contributes to serotonin and tryptamine metabolism and has been proposed as the enzyme responsible for biosynthesis of endogenous dimethyltryptamine in mammals. By detecting INMT, researchers can examine its distribution, activity, and regulation in diverse tissues.

Western blotting with INMT antibody detects enzyme expression in liver and brain samples. Immunohistochemistry maps expression in neuronal and peripheral tissues, while immunofluorescence highlights cytoplasmic localization within cells. These approaches provide powerful tools for characterizing INMT biology.

INMT has clinical and pharmacological significance. Altered expression has been linked to pulmonary hypertension, schizophrenia, and other neuropsychiatric conditions. Genetic polymorphisms in INMT influence enzyme activity and metabolic profiles. By applying INMT antibody, scientists can explore how changes in tryptamine metabolism contribute to disease and therapeutic response.

INMT also participates in xenobiotic metabolism by methylating exogenous compounds. Its role in detoxification pathways expands its relevance to pharmacology and toxicology. INMT antibody supports studies into how methyltransferases regulate chemical balance in the body.

Research continues to evaluate INMT in neurological function, where dimethyltryptamine has been implicated in altered states of consciousness and potential therapeutic applications. Investigating INMT expression with antibody based methods provides insights into both fundamental biology and emerging areas of translational research.

INMT antibody from NSJ Bioreagents provides reliable specificity for detecting indolethylamine N methyltransferase. Its performance across assays ensures accurate results in metabolism, neuroscience, and pharmacology.

UniProt: O95050