Human Papilloma Virus 18 E6 (HPV-18 E6) Antikörper

Produktnummer ABIN7881130

Der Maus Monoklonal anti-Human Papilloma Virus 18 E6 Antikörper (Klon HPV18-1297) (ABIN7881130) detektiert spezifisch Human Papilloma Virus 18 E6 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human Papillomavirus 18 (HPV-18).

Kurzübersicht für Human Papilloma Virus 18 E6 (HPV-18 E6) Antikörper (ABIN7881130)

Target: Human Papilloma Virus 18 E6 (HPV-18 E6)

Reaktivität: Human Papillomavirus 18 (HPV-18)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: HPV18-1297

Produktdetails

Verwendungszweck: HPV18 E6 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: HPV18 E6-i²-galactosidase fusion protein was used as the immunogen for this HPV18 E6 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HPV18 E6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the HPV18 E6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: Human Papilloma Virus 18 E6 (HPV-18 E6)

Andere Bezeichnung: HPV18 E6

Substanzklasse: Viral Protein

Hintergrund: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.