ATRX Antikörper

Produktnummer ABIN7880992

Der Maus Monoklonal anti-ATRX Antikörper (Klon 23c) (ABIN7880992) detektiert spezifisch ATRX in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ATRX Antikörper (ABIN7880992)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 23c

Produktdetails anti-ATRX Antikörper

Verwendungszweck: ATRX Antibody / RAD54 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human ATRX protein was used as the immunogen for this ATRX antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ATRX antibody to be titered up or down for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX

Hintergrund: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 i± to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome.

UniProt: P46100