FOXL2 Antikörper

Produktnummer ABIN7880811

Der Kaninchen Polyklonal anti-FOXL2 Antikörper wird verwendet zum Nachweis von FOXL2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, FACS und IHC (p).

Kurzübersicht für FOXL2 Antikörper (ABIN7880811)

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FOXL2 Antikörper

Verwendungszweck: FOXL2 Antibody

Sequenz: ACARQPELAM MHCSYWDHD

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids ACARQPELAMMHCSYWDHD from the human protein were used as the immunogen for the FOXL2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FOXL2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FOXL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu FOXL2

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Andere Bezeichnung: FOXL2

Hintergrund: The forkhead transcription factor gene, FOXL2 located in blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) critical region on chromosome 3q23. Consistent with an involvement in BPES, FOXL2 is selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles, in adult humans, it appears predominantly in the ovary. FOXL2 haploinsufficiency may cause BPES types I and II by the effect of a null allele and a hypomorphic allele, respectively. Furthermore, in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect. FOXL2 mutations can also cause gonadal dysgenesis or premature ovarian failure(POF) in women, as well as eyelid/forehead dysmorphology in both sexes.

UniProt: P58012

Pathways: Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity