Rekombinanter EIF3A Antikörper

Produktnummer ABIN7880749

Der Kaninchen Monoklonal anti-EIF3A Antikörper (Klon 31E29) (ABIN7880749) detektiert spezifisch EIF3A in WB, IHC, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter EIF3A Antikörper (ABIN7880749)

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser EIF3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 31E29

Produktdetails anti-EIF3A Antikörper

Verwendungszweck: EIF3A Antibody / Eukaryotic translation initiation factor 3 subunit A

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human eIF3A was used as the immunogen for the EIF3A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the EIF3A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the EIF3A antibody at -20oC.

Details zu EIF3A

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Andere Bezeichnung: EIF3A

Hintergrund: EIF3A antibody detects eukaryotic translation initiation factor 3 subunit A, the largest subunit of the EIF3 complex. EIF3A is a central scaffold protein that coordinates the assembly of other EIF3 subunits, promoting formation of the 43S preinitiation complex. This step is essential for recruiting mRNA and initiating protein synthesis. EIF3A contributes to translation of specific mRNAs involved in cell cycle progression, signaling, and stress adaptation.

Research using EIF3A antibody has highlighted the protein's role in both normal cellular growth and cancer biology. EIF3A is frequently overexpressed in tumors, where it selectively enhances translation of oncogenes and suppresses translation of tumor suppressors. This imbalance contributes to tumor proliferation, survival, and metastasis. Studies have linked EIF3A to lung cancer, breast cancer, and hepatocellular carcinoma, making it a valuable biomarker and potential therapeutic target.

Beyond cancer, EIF3A is essential for embryonic development and cellular stress responses. Its regulation ensures that cells adapt translation rates during nutrient deprivation, hypoxia, or DNA damage. EIF3A dysfunction disrupts protein homeostasis, leading to impaired cell survival or uncontrolled growth. Because of this, EIF3A has become an important research focus in studies of translation control and disease mechanisms.

Antibodies against EIF3A are validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation. These reagents enable researchers to monitor EIF3A protein levels, examine subcellular localization, and analyze interactions within the EIF3 complex. Clone-based versions provide specificity required to distinguish EIF3A from other EIF3 subunits.

NSJ Bioreagents supplies this EIF3A antibody to support research in translation initiation, cancer pathways, and developmental biology.

UniProt: Q14152

Pathways: Ribonucleoprotein Complex Subunit Organization