CRTC1 Antikörper

Produktnummer ABIN7880509

Der Kaninchen Polyklonal anti-CRTC1 Antikörper (ABIN7880509) detektiert spezifisch CRTC1 in WB, IF, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CRTC1 Antikörper (ABIN7880509)

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CRTC1 Antikörper

Verwendungszweck: TORC1/CRTC1 Antibody

Sequenz: DAYYEQQMAA RQANALSHQL EQFNMMENAI S

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids DAYYEQQMAARQANALSHQLEQFNMMENAIS were used as the immunogen for the TORC1/CRTC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TORC1/CRTC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TORC1/CRTC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: TORC1/CRTC1

Hintergrund: CRTC1 (CREB-Regulated Transcription Coactivator 1), also known as MECT1, TORC1 or KIAA0616, is a protein that in humans is encoded by the CRTC1 gene. By sequence analysis, Tonon et al. (2003) mapped the CRTC1 gene to chromosome 19p13. Kovacs et al. (2007) found that Torc1 was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Mair et al. (2011) demonstrated that CRTC1 is a direct AMPK target, and interacts with the CREB homolog-1 (CRH1) transcription factor in vivo. The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms.

UniProt: Q6UUV9