Claudin 3 Antikörper

Produktnummer ABIN7880446

Der Kaninchen Polyklonal anti-Claudin 3 Antikörper (ABIN7880446) detektiert spezifisch Claudin 3 in WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Ratte.

Kurzübersicht für Claudin 3 Antikörper (ABIN7880446)

Target: Claudin 3 (CLDN3)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Claudin 3 Antikörper

Verwendungszweck: Claudin 3 Antibody / CLDN3

Sequenz: RDKYAPTKIL YSAPRST

Aufreinigung: Affinity purified

Immunogen: Amino acids RDKYAPTKILYSAPRST from the mouse protein were used as the immunogen for the Claudin 3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Claudin 3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Claudin 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Claudin 3

Target: Claudin 3 (CLDN3)

Andere Bezeichnung: Claudin 3

Hintergrund: Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology.

UniProt: Q9Z0G9

Pathways: Hepatitis C