Claudin 16 Antikörper

Produktnummer ABIN7880445

Der Kaninchen Polyklonal anti-Claudin 16 Antikörper wird verwendet zum Nachweis von Claudin 16 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, FACS und IF.

Kurzübersicht für Claudin 16 Antikörper (ABIN7880445)

Target: Claudin 16 (CLDN16)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-Claudin 16 Antikörper

Verwendungszweck: Claudin 16 Antibody / CLDN16

Sequenz: KSYSAPRTET AKMYAVDTRV

Aufreinigung: Affinity purified

Immunogen: Amino acids KSYSAPRTETAKMYAVDTRV from the human protein were used as the immunogen for the Claudin 16 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Claudin 16 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Claudin 16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Claudin 16

Target: Claudin 16 (CLDN16)

Andere Bezeichnung: Claudin 16

Hintergrund: Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

UniProt: Q9Y5I7

Pathways: Hepatitis C