CENPB Antikörper

Produktnummer ABIN7880385

Der Kaninchen Polyklonal anti-CENPB Antikörper wird verwendet zum Nachweis von CENPB in Proben von Human. Er wurde validiert für WB, IF und FACS.

Kurzübersicht für CENPB Antikörper (ABIN7880385)

Target: CENPB (Centromere Protein B (CENPB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-CENPB Antikörper

Verwendungszweck: CENPB Antibody / Centromere protein B

Sequenz: HLEHDLVHVT RKNHA

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids HLEHDLVHVTRKNHA from the human protein were used as the immunogen for the CENPB antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CENPB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CENPB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CENPB

Target: CENPB (Centromere Protein B (CENPB))

Andere Bezeichnung: CENPB

Hintergrund: Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

UniProt: P07199