Rekombinanter CRABP2 Antikörper

Produktnummer ABIN7880384

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch CRABP2 in WB, IHC, IF, ICC und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter CRABP2 Antikörper (ABIN7880384)

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CRABP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 30C81

Produktdetails anti-CRABP2 Antikörper

Verwendungszweck: CRABP2 Antibody / Cellular retinoic acid-binding protein 2

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CRABP2 was used as the immunogen for the CRABP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CRABP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the CRABP2 antibody at -20oC.

Details zu CRABP2

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Andere Bezeichnung: CRABP2

Hintergrund: CRABP2 antibody detects cellular retinoic acid-binding protein 2, encoded by the CRABP2 gene. Alternate names include CRABP-II, cellular retinoic acid-binding protein type II, and RA-binding protein 2. CRABP2 is a cytoplasmic protein that binds retinoic acid with high affinity, delivering it to the nucleus to interact with retinoic acid receptors (RARs). This shuttling mechanism ensures efficient retinoic acid signaling, which regulates cell differentiation, growth, and development. Structurally, CRABP2 belongs to the fatty acid-binding protein family, characterized by a beta-barrel fold that binds hydrophobic ligands.

CRABP2 antibody is widely applied in developmental biology, cancer research, and dermatology. Retinoic acid is essential for embryonic patterning, limb development, and organogenesis, and CRABP2 ensures delivery of ligand to nuclear receptors. In skin, CRABP2 regulates keratinocyte differentiation and retinoid responses, linking it to dermatological therapies. In cancer biology, CRABP2 expression modulates sensitivity to retinoids, influencing proliferation and apoptosis.

Applications of CRABP2 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects CRABP2 protein in cell and tissue lysates, immunohistochemistry maps expression in embryonic and tumor tissues, and immunofluorescence highlights cytoplasmic and nuclear localization. These methods support research into retinoid signaling in diverse contexts.

Dysregulation of CRABP2 is linked to developmental abnormalities, cancer progression, and skin disease. Overexpression promotes retinoid sensitivity in some cancers, while downregulation confers resistance. By applying CRABP2 antibody, researchers can study how retinoid signaling contributes to disease and therapy response.

CRABP2 interacts with nuclear RARs, cytoplasmic enzymes, and signaling molecules. This positions it as a central mediator of vitamin A biology. NSJ Bioreagents provides CRABP2 antibody with validated specificity, supporting accurate detection in studies of development, cancer, and dermatology.

UniProt: P29373