Rekombinanter CD163L1 Antikörper

Produktnummer ABIN7880238

Der Kaninchen Monoklonal anti-CD163L1 Antikörper wird verwendet zum Nachweis von CD163L1 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter CD163L1 Antikörper (ABIN7880238)

Target: CD163L1 (CD163 Molecule-Like 1 (CD163L1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CD163L1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: 31C59

Produktdetails anti-CD163L1 Antikörper

Verwendungszweck: CD163L1 Antibody / CD163 like 1 / CD163b

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human CD163L1 was used as the immunogen for the CD163L1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CD163L1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the CD163L1 antibody at -20oC.

Details zu CD163L1

Target: CD163L1 (CD163 Molecule-Like 1 (CD163L1))

Andere Bezeichnung: CD163L1

Hintergrund: CD163L1 antibody detects CD163 like 1 protein, also called CD163b, encoded by the CD163L1 gene. CD163 like 1 is a scavenger receptor expressed on subsets of monocytes and macrophages, structurally related to CD163 but with distinct ligand binding and immune functions. CD163L1 antibody provides researchers with a valuable tool to study macrophage biology, innate immunity, and inflammatory disease.

CD163 like 1 is a member of the scavenger receptor cysteine-rich family and localizes to the plasma membrane of immune cells. Research using CD163L1 antibody has shown that this receptor binds hemoglobin haptoglobin complexes and other ligands, contributing to clearance of hemoglobin and modulation of inflammation. Unlike CD163, CD163L1 expression is restricted to specific immune cell subsets, suggesting specialized functions in innate defense.

In immune regulation, CD163L1 influences cytokine responses and macrophage polarization. Studies with CD163L1 antibody have demonstrated that its engagement alters production of pro- and anti-inflammatory mediators, shaping immune responses during infection and tissue repair. Dysregulation of CD163L1 expression has been associated with chronic inflammation and autoimmune disorders.

Beyond immunity, CD163L1 has been implicated in cardiovascular and metabolic diseases. Research using CD163L1 antibody has revealed associations with atherosclerosis, where scavenger receptor activity influences lipid uptake and foam cell formation. In metabolic disease, altered expression may contribute to chronic low-grade inflammation in obesity and diabetes. These findings expand the role of CD163L1 beyond classical scavenger functions to systemic disease processes.

CD163L1 antibody is applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting confirms protein size, immunohistochemistry shows tissue localization, and flow cytometry quantifies expression on immune subsets. These methods make CD163L1 antibody useful in immunology and pathology research.

By providing validated CD163L1 antibody reagents, NSJ Bioreagents supports research into macrophage biology, innate immunity, and inflammatory disease. Detection of CD163 like 1 protein enables researchers to examine how scavenger receptors shape immune responses and disease progression.

UniProt: Q9NR16