Rekombinanter CABP1 Antikörper

Produktnummer ABIN7880136

Der Kaninchen Monoklonal anti-CABP1 Antikörper wird verwendet zum Nachweis von CABP1 in Proben von Human und Maus. Er wurde validiert für WB, ICC und IF.

Kurzübersicht für Rekombinanter CABP1 Antikörper (ABIN7880136)

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CABP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: 31C60

Produktdetails anti-CABP1 Antikörper

Verwendungszweck: CABP1 Antibody / Calcium binding protein 1

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CABP was used as the immunogen for the CABP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CABP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the CABP1 antibody at -20oC.

Details zu CABP1

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Andere Bezeichnung: CABP1

Hintergrund: CABP1 antibody detects calcium binding protein 1, a neuronal calcium binding protein encoded by the CABP1 gene. CABP1 belongs to the calmodulin like protein family and contains EF hand domains that sense calcium signals. It regulates calcium channels, neurotransmitter release, and synaptic plasticity. CABP1 is predominantly expressed in brain and retina, where it modulates signaling events essential for neuronal communication and vision.

CABP1 antibody is widely used in neuroscience and sensory biology research. CABP1 interacts with L type calcium channels and inositol 1,4,5 triphosphate receptors, tuning calcium signaling in neurons. It plays roles in learning, memory, and synaptic adaptation. In the retina, CABP1 modulates photoreceptor signaling and contributes to visual processing. By detecting CABP1, researchers can evaluate how neuronal calcium sensors shape cellular signaling.

In western blot assays, CABP1 antibody detects protein bands corresponding to expected isoforms in neural tissue. Immunohistochemistry highlights expression in hippocampus and retina, while immunofluorescence reveals subcellular localization at synapses and dendrites. These methods support detailed analysis of calcium binding proteins in neurons.

Altered CABP1 expression has been linked to neurological disorders including schizophrenia and epilepsy, where calcium signaling is disrupted. CABP1 also influences neuronal excitability and response to stress, suggesting broader roles in neuroprotection. By applying CABP1 antibody, scientists can investigate how calcium sensors contribute to brain function and disease mechanisms.

CABP1 antibody from NSJ Bioreagents offers strong specificity for detecting calcium binding protein 1 across tissues. Its reliable performance across multiple applications ensures accurate results, supporting research into calcium regulation in neural signaling and vision.

UniProt: Q9NZU7

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity